January 24, 2018
UBC researchers have been awarded $43m for 65 projects at the university and its affiliated health authority research centres through the Canadian Institutes of Health Research's (CIHR) latest Project Grant competition.
A total of $372m was awarded nationally to support Canadian researchers to study the full spectrum of health issues affecting the lives of Canadians.
national release | Backgrounder
Research Grants
59 projects at UBC and our affiliated health authority research centres received $42.4m in research grant funding.
- Abraham, Ninan
CD127 in the development and function of Type 2 Innate Lymphoid Cells (ILC2s).
$ 1,036,575 - Auld, Vanessa J
Mechanisms of tricellular junction formation and regulation
$ 719,100 - Barbic, Skye P
Healthier by doing: Testing the effectiveness of a youth-centred employment/education intervention for young adults with mental illness
$ 302,175 - Bernatchez, Pascal N
The critical role of plasma cholesterol in the pathogenesis of muscular dystrophy
$ 294,524 - Boyd, John H
Organ donation after cardiac death: optimizing the donor heart.
$ 504,900 - Bromme, Dieter
Ectosteric inhibitors of cathepsin K: their mechanism and in vivo efficacy
$ 956,250 - Brown, Carolyn J
Role of XIST in human X-chromosome inactivation
$ 963,900 - Brubacher, Jeffrey R
Predictors of poor health and functional recovery following road trauma: An emergency department inception cohort study.
$ 875,925 - Buttyan, Ralph
Interference with Gli to Control Castration Resistant Prostate Cancer
$ 344,250 - Buxton, Jane
Opioid Prescribing Evaluation and Research Activities (OPERA)
$ 520,201 - Camp, Patricia G
Niwh Yizt'iyh Hilht'iz Nets'eelh'iyh - Strengthening our Bodies: A Community-based Research Project to Create Pulmonary Tele-Rehabilitation in Remote and Rural First Nations Communities in Northern British Columbia
$ 803,250 - Camp, Patricia G
Bayis Il Tus - A Strong Breath: Community-Based Research to Identify the Prevalence of and Contributors to Chronic Obstructive Pulmonary Disease in Remote and Rural First Nations Communities in British Columbia
$ 791,775 - Carlsten, Christopher
Does traffic-related air pollution reduce the effectiveness of corticosteroids in asthma treatment?
$ 673,200 - Chen, Frances
Assessing the role of adolescent hormonal contraceptive use on risk for depression
$ 466,652 - Cherkasov, Artem
Design and evaluation of small molecules that target the dimerization interface of full-length and splice-variant forms of the androgen receptor as a potential treatment for advanced prostate cancer
$ 459,000 - Cote, Hélène
Placenta mitochondrial dysfunction and preterm birth
$ 1,239,300 - Dong, Xuesen
RNA splicing regulates prostate cancer progression to hormone therapy resistant neuroendocrine tumors
$ 699,975 - Fairbairn, Nadia S
Repurposing slow-release oral morphine as new oral alternative for the treatment of opioid use disorder
$ 585,225 - Fedida, David
Biophysical properties and regulation of KCNQ1 and KCNE(x) ion channel complexes.
$ 627,300 - Field, Thalia S
SECRET: Study of rivaroxaban for CeREbral venous Thrombosis
$ 191,250 - Francis, Gordon A
Relative deficiency of lysosomal acid lipase in arterial smooth muscle cells as a novel target for atherosclerosis treatment and prevention
$ 512,550 - Gantt, Soren M
Viral determinants of natural human cytomegalovirus transmission
$ 1,143,675 - Gill, Jagbir S
Canadian-Australasian Randomized Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease (CARSK)
$ 2,237,625 - Gleave, Martin E
Preclinical development of a novel androgen receptor antagonist to treat castration-resistant prostate cancer
$ 351,900 - Hackett, Tillie-Louise
The Role of Small Airways Disease Heterogeneity in Asthma
$ 675,342 - Holt, Rob
Engineering T cells to overcome an immunosuppressive solid tumour microenvironment
$ 150,000 - Hutcheon, Jennifer A
Short term benefits but long term harm? Assessing the consequences of antenatal corticosteroid administration for child neurodevelopment
$ 221,851 - Jan, Eric
Host cell protein substrates of enterovirus proteases
$ 726,750 - Jiang, Xiaoyan
Targeting Key Autophagy Proteins/Pathways for Treatment of Human Leukemia
$ 787,950 - Kim, Hugh
Targeting platelet-specific molecules in periodontal disease
$ 856,800 - Krahn, Andrew D
Risk prediction of sudden death in arrhythmogenic right ventricular cardiomyopathy: the Canadian ARVC registry
$ 772,650 - Krassioukov, Andrei
Transient Hypertension and Vascular-Cognitive Impairment after Spinal Cord Injury: Benefit of Passive Exercise
$ 267,751 - Kurtz, Donna L
Building Indigenous Pathways for Diabetes and Obesity Prevention and Management with Urban and Rural Communities in BC
$ 849,150 - Larjava, Hannu S
Epithelial alpha-v-beta-6 integrin: critical regulator of periodontal inflammation
$ 879,750 - LeMoult, Joelle
Characterizing the Peripheral Biology of Depression, Social Anxiety, and their Comorbidity
$ 573,750 - Lima, Viviane D
What will it take to decrease the burden of the HIV and STI epidemics among MSM in British Columbia, Canada? A sexual network modeling analysis, combining syndemic theory, to evaluate the impact of behavioural and biomedical interventions for HIV and STI prevention
$ 810,900 - Lynn, Francis C
Cell cycle regulation of human pancreatic endocrine cell development.
$ 692,325 - McGrail, Kimberlyn M
Privacy-Preserving Record Linkage: Testing and Potential Implementation in Canada
$ 413,100 - McManus, Bruce M
HEARTBiT: A novel multi-marker blood test for management of acute cardiac allograft rejection
$ 2,180,250 - Mcnagny, Kelly M
Modulation of Innate Immune Responses as a Therapy for Muscular Dystrophy
$ 956,250 - Measday, Vivien R
Targeting of a mobile genetic element into the genome using budding yeast as a model system
$ 669,375 - Moritz, Orson L
Mechanisms of cell death in inherited retinal degeneration caused by rhodopsin mutations
$ 856,800 - Moritz, Orson L
Mechanisms of rod and cone disk membrane synthesis and quality control in normal and diseased retina.
$ 745,875 - Naus, Christian C
Pannexin1 mediation of stroke recovery responses: Sex and sex steroid influences
$ 692,325 - Panenka, William J
Characterization of Traumatic brain injury as a contributor to chronic neuropsychiatric and neurocognitive impairment in a marginally housed population.
$ 577,576 - Perrin, David M
Dual-Mode PET imaging agents for PET imaging cancer and visualizing tumor margins
$ 596,700 - Perrin, David M
Alpha-amanitin: synthetic derivatives for applications in targeted therapy
$ 405,450 - Phillips, Anthony G
Role of ionotropic glutamate receptors and synaptic plasticity in development of novel fast-acting antidepressants.
$ 967,725 - Reid, Gregor
Identifying infection-induced determinants of paediatric acute lymphoblastic leukaemia progression
$ 688,500 - Shoveller, Jean A
Women's overdose risk environments and the response to the overdose crisis in Vancouver, Canada
$ 451,350 - Tanentzapf, Guy
Regulation of Stem-Cell niche interactions in the hematopoietic system by occluding and gap junctions.
$ 768,825 - Tremlett, Helen L
Prescription Drug Safety and Effectiveness in Multiple Sclerosis [DRUMS]: a population-based, multi-province platform for comprehensive pharmacovigilance
$ 1,220,175 - van den Bosch, Matilda
Born to be Wise: Impact of Modifiable Early-life Environmental Exposures on the Health and Development of Children
$ 351,900 - Vedam, Saraswathi
Giving Voice to Mothers; Measuring access to high quality, respectful maternity care in Canada
$ 883,575 - Winstanley, Catharine A
The effects of reward cues on risky decision making: the role of dopamine and relevance to addiction
$ 612,000 - Wyatt, Alexander W
Predicting therapy resistance in castration-resistant prostate cancer with circulating tumor DNA
$ 516,375 - Yong, Paul
Sexual pain in endometriosis: role of somatic mutations and local neurogenesis
$ 976,905 - Zeng, Haishan
Real-time Endoscopic Raman Spectroscopy for Improving Dysplasia/Colorectal Cancer Detection in Patients with Inflammatory Bowel Diseases
$ 508,725 - Zhou, Youwen
Role of CLEC12B+ macrophages in the pathogenesis of vitiligo and melanoma
$ 745,875
Bridge Grants
A further six projects recieved $600,000 through bridge grants.
- Hunt, Michael A
Shoe insoles designed to target foot and knee symptoms in people with knee osteoarthritis: A randomized controlled study
$100,000 - Nabi, Ivan R
Caveolin-1 regulation of focal adhesion tension and the breast cancer cell response to matrix stiffness
$100,000 - Seamans, Jeremy K
How is anxiety represented in the anterior cingulate cortex?
$100,000 - Verchere, Bruce C
Islet macrophages: regulators of beta cell function in health and diabetes
$100,000 - Wellington, Cheryl L
Precision Fluid Biomarkers of Traumatic Brain Injury
$100,000 - Wilson, David R
Development, assessment and application of a new method for characterizing degenerative lumbar spondylolisthesis in the symptomatic upright posture.
$100,000