November 1, 2021
The Canadian Institutes of Health Research announced the results of the Project Grant: Spring 2021 competition.
Awards included 422 research grants, plus 4 bridge grants, for a total investment of approximately $325 million. In addition, 59 priority announcement grants were funded for a total amount of $9,815,000 and 11 supplemental prizes were awarded for a total of $555,000
A total of 59 projects led by UBC researchers were awarded funding of $41.1 million
- 50 projects led by UBC researchers were awarded Project Grants totaling $39.2 million
- 7 projects led by UBC researchers were awarded Priority Announcement funding totaling $1.7 million
- 2 projects led by UBC researchers were awarded Bridge Grants totaling $0.2 million
UBC-led Projects awarded Project Grant Funding
- Evaluating and Informing Canada's Proposed Pharmaceutical Price Regulations
Principal Investigator: Anis, Aslam H (School of Population and Public Health / CHEOS)
Research Institute: Centre for Health Evaluation & Outcome Sciences
Other PI(s): Zhang, Wei
$581,400 (4 years)
- Obstructive Sleep Apnea and Long-term Health Consequences
Principal Investigator: Ayas, Najib (Medicine / CHEOS)
Research Institute: University of British Columbia
$1,445,850 (5 years)
- A Novel Formulation of the Anticancer Drug Candidate CX5461 that Relies on Metal Chemistry and Liposomal Nanotechnology: Development for use in Treatment of Pancreatic Cancer's with BRCA Deficiencies; an Orphan Indication
Principal Investigator: Bally, Marcel B (Experimental Therapeutics)
Research Institute: BC Cancer
$765,000 (5 years)
- Options for Increasing Plasma Supply in Canada: A Health Economic Preference and Modelling Study (HEMO-CAN)
Principal Investigator: Bansback, Nicholas (School of Population and Public Health)
Research Institute: University of British Columbia
$328,950 (3 years)
- Targeting cancer-associated fibroblasts and tumour hypoxia with angiotensin II receptor blockers
Principal Investigator: Bennewith, Kevin L (Pathology and Laboratory Medicine)
Research Institute: BC. Cancer
$979,200 (5 years)
- Circumstances and Outcome of Active Transportation Injuries: An Inception Cohort Study.
Principal Investigator: Brubacher, Jeffrey R (Emergency Medicine)
Research Institute: Vancouver Coastal Health Research Institute
$823,141 (4 years)
- A new potential therapeutic target for type 2 diabetes: Delineating the mechanisms of its actions
Principal Investigator: Conway, Edward M (Center for Blood Research)
Research Institute: University of British Columbia
$765,000 (5 years)
- Predictive modeling in multiple sclerosis: using real world data to inform practice, policy, and research
Principal Investigator: Cragg, Jacquelyn J (Pharmaceutical Sciences)
Research Institute: University of British Columbia
Other PI(s): Lynd, Larry D
$470,475 (4 years)
- Design a Double-Bolt Lock to Control Cancer Cell Growth
Principal Investigator: Dong, Xuesen (Urologic Sciences)
Research Institute: University of British Columbia
$910,350 (5 years)
- Indispensable Amino Acid Requirements in Pregnancy and Lactation
Principal Investigator: Elango, Rajavel (Pediatrics)
Research Institute: University of British Columbia
$726,750 (5 years)
- Peptidoglycan remodeling in Campylobacter jejuni: effects on shape and pathogenesis
Principal Investigator: Gaynor, Erin C (Microbiology and Immunology)
Research Institute: University of British Columbia
$956,250 (5 years)
- Addressing key knowledge gaps in testing to inform STI prevention & control strategies
Principal Investigator: Gilbert, Mark P (School of Population and Public Health)
Research Institute: B.C. Centre for Disease Control (Vancouver)
Other PI(s): Wong, Jason Lavoie, Martin
$306,000 (2 years)
- The contribution of sex differences to small airways disease in chronic obstructive pulmonary disease
Principal Investigator: Hackett, Tillie-Louise (Anesthesiology, Pharmacology and Therapeutics)
Research Institute: University of British Columbia
$730,576 (5 years)
- Age-associated B cells in viral infection and autoimmune diseases
Principal Investigator: Horwitz, Marc S (Microbiology and Immunology)
Research Institute: University of British Columbia
$1,128,376 (5 years)
- Translation initiation via factorless internal ribosome entry site mechanisms
Principal Investigator: Jan, Eric (Biochemistry and Molecular Biology)
Research Institute: University of British Columbia
$918,000 (5 years)
- Making an impact on rural health: Scaling-out and evaluating the implementation and effectiveness of an evidence-based diabetes prevention program across Interior British Columbia
Principal Investigator: Jung, Mary E (School of Health and Exercise Sciences)
Research Institute: University of British Columbia
$585,224 (4 years)
- Side by Side: Identifying strategies to address the health and social needs of youth who use stimulants
Principal Investigator: Knight, Rodney E (Medicine)
Research Institute: British Columbia Centre on Substance Use
Other PI(s): Fast, Danya
$512,550 (3 years)
- Prediction of Cognitive and Motor Symptom Progression in Multiple Sclerosis Using Myelin Imaging
Principal Investigator: Kolind, Shannon (Medicine/Neurology)
Research Institute: University of British Columbia
Other PI(s): Traboulsee, Anthony
$504,900 (3 years)
- Rise & Shine: Promoting Sleep Quality in Chronic Stroke with Exercise
Principal Investigator: Liu-Ambrose, Teresa Y (Physical Therapy)
Research Institute: University of British Columbia
$573,751 (5 years)
- Understanding the effects of ERK hyperactivation in cancer: implications for therapy
Principal Investigator: Lockwood, William W (Pathology and Laboratory Medicine)
Research Institute: BC Cancer
$956,250 (5 years)
- Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Stage III Colorectal Cancer: A Multicentre Phase II/III Randomised Controlled Trial (DYNAMIC-III)
Principal Investigator: Loree, Jonathan M (Medicine)
Research Institute: BC Cancer
Other PI(s): O'Callaghan, Christopher J
$1,426,724 (6 years)
- Devices for Image-Guided Biopsy of Peripheral Lung Nodules
Principal Investigator: Macaulay, Calum E (Pathology and Laboratory Medicine)
Research Institute: BC Cancer
$386,326 (3 years)
- Building and rebuilding brain white matter with endogenous neural stem cells
Principal Investigator: Miller, Freda D (Michael Smith Laboratories)
Research Institute: University of British Columbia
$826,200 (5 years)
- FLASH radiotherapy - mechanisms and translational studies
Principal Investigator: Minchinton, Andrew I (Pathology and Laboratory Medicine)
Research Institute: BC Cancer
$918,000 (4 years)
- Evaluating Microdosing in Emergency Departments: A Randomized Controlled Trial Comparing the Effectiveness of Buprenorphine/Naloxone Microdosing vs. Standard Dosing (EMED Study)
Principal Investigator: Moe, Jessica (Emergency Medicine)
Research Institute: University of British Columbia
Other PI(s): Lock, Kurt Slaunwhite, Amanda K Nosyk, Bohdan P Davison, Carolyn Wong, Hubert H Hohl, Corinne M Carter, Connie I Holroyd, Brian R
$1,184,681 (3 years)
- Uptake and gaps in HIV pre-exposure prophylaxis (PrEP) use among HIV-negative gay, bisexual, and other men who have sex with men (gbMSM) in Metro Vancouver, Canada before, during and following COVID-19
Principal Investigator: Moore, David M (Medicine)
Research Institute: St. Paul's Hospital
Other PI(s): Lachowsky, Nathan J
$180,000 (3 years)
- Improving access to family planning services for Indigenous peoples through storytelling
Principal Investigator: Munro, Sarah B (Obstetrics and Gynecology)
Research Institute: University of British Columbia
Other PI(s): Malhotra, Unjali Jubinville, Danette S Kelly, Miranda D
$715,275 (4 years)
- Detection of early relapse using circulating miR371a-3p in patients with clinical stage I testicular germ cell tumors
Principal Investigator: Nappi, Lucia (Urologic Sciences)
Research Institute: Vancouver Prostate Centre
$76,500 (1 years)
- 'Real-time' measures of anxiety and physical activity in 15-18 year olds with prenatal antidepressant exposure
Principal Investigator: Oberlander, Timothy F (Pediatrics)
Research Institute: University of British Columbia
$730,576 (4 years)
- Overcoming Dihydrofolate Reductase Inhibitor Resistance Using Pyrimethamine-inspired Proteolysis Targeting Chimeras
Principal Investigator: Page, Brent (Pharmaceutical Sciences)
Research Institute: University of British Columbia
$812,814 (5 years)
- Antibiotic Use and Asthma Incidence: Population Based Retrospective Cohort Investigations in BC and Manitoba.
Principal Investigator: Patrick, David M (School of Population and Public Health)
Research Institute: University of British Columbia
$175,951 (2 years)
- Leveraging Trans-Canada Expertise and Resources to Design and Evaluate Novel Auger Electron-Emitting Radioimmunotherapies (RIT) for Metastatic Triple-Negative Breast Cancer (TNBC)
Principal Investigator: Radchenko, Valery (Chemistry)
Research Institute: TRIUMF
Other PI(s): Reilly, Raymond M
$562,275 (4 years)
- Role of altered endoplasmic reticulum calcium regulation and the N-methyl-D-aspartate (NMDA) receptor signaling in cortico-striatal synaptic dysfunction: Opportunities for therapy in prodromal Huntington disease
Principal Investigator: Raymond, Lynn A (Psychiatry)
Research Institute: University of British Columbia
$1,105,426 (5 years)
- The ASSET Study: Assessing economic transitions and their impacts on health and well-being
Principal Investigator: Richardson, Lindsey (Sociology)
Research Institute: University of British Columbia
$818,550 (3 years)
- Role of cardiac lipoprotein lipase in diabetic heart disease.
Principal Investigator: Rodrigues, Brian B (Pharmaceutical Sciences)
Research Institute: University of British Columbia
$696,150 (5 years)
- Advancing virtual care in stroke rehabilitation: A randomized controlled trial investigating the TeleRehabilitation with Aims to Improve Lower Extremity Recovery Post-Stroke (TRAIL) program
Principal Investigator: Sakakibara, Brodie M (Occupational Therapy)
Research Institute: University of British Columbia
Other PI(s): Tang, Ada
$279,224 (3 years)
- Illuminating the genetic forces driving development by profiling with single cell transcriptomics at thousands of time-points
Principal Investigator: Schiebinger, Geoffrey (Mathematics)
Research Institute: University of British Columbia
$849,150 (5 years)
- Graded exposure therapy for fear avoidance behaviour (GET FAB) after concussion
Principal Investigator: Silverberg, Noah (Psychology)
Research Institute: University of British Columbia
$761,176 (4 years)
- A Novel Approach to Discover Therapeutic and Biomarker Targets and Enable Precision Health in COPD: TORCH (Towards Omics and imaging to Revolutionize COPD Health)
Principal Investigator: Sin, Donald (Medicine)
Research Institute: University of British Columbia
$952,426 (5 years)
- Comprehensive characterizations for the molecular and evolutionary mechanisms of beta-lactam 'resistome'
Principal Investigator: Tokuriki, Nobuhiko (Michael Smith Laboratories / Biochemistry and Molecular Biology)
Research Institute: University of British Columbia
$1,032,750 (5 years)
- Understanding Human Primary Atopic Disorders
Principal Investigator: Turvey, Stuart E (Pediatrics)
Research Institute: University of British Columbia
Other PI(s): Biggs, Catherine M
$765,000 (5 years)
- Colonic Goblet Cells and Mucus: Defining Their Roles in Host Defense and Mucosal Protection
Principal Investigator: Vallance, Bruce A (Pediatrics)
Research Institute: University of British Columbia
$918,000 (5 years)
- Blocking the metastatic spread of uveal melanoma
Principal Investigator: Van Raamsdonk, Catherine D (Medical Genetics)
Research Institute: University of British Columbia
$1,021,276 (5 years)
- A comprehensive study on bone quality for the prediction of second hip fractures
Principal Investigator: Wang, Rizhi (Materials Engineering)
Research Institute: University of British Columbia
Other PI(s): Guy, Pierre
$833,850 (5 years)
- Exploit the metabolic vulnerabilities in SWI/SNF-deficient cancer
Principal Investigator: Wang, Yemin (Pathology and Laboratory Medicine)
Research Institute: Vancouver Coastal Health Research Institute
$688,501 (4 years)
- Smart Discharges for Mom+Baby: Saving mother-newborn dyads by developing a predictive risk model to identify vulnerable dyads and guide delivery of evidence-based, locally-informed interventions for targeted post-discharge care.
Principal Investigator: Wiens, Matthew O (Anesthesiology, Pharmacology and Therapeutics)
Research Institute: University of British Columbia
$566,100 (3 years)
- Genomic dissection of de novo metastatic prostate cancer prior to treatment
Principal Investigator: Wyatt, Alexander W (Urologicasl Sciences)
Research Institute: University of British Columbia
Other PI(s): Chi, Kim N Ost, Piet
$734,400 (3 years)
- Identifying a high-resolution map of dynamic cellular and molecular trajectories during the development of a whole mammalian body
Principal Investigator: Yachie, Nozomu (School of Biomedical Engineering)
Research Institute: University of British Columbia
$1,143,676 (5 years)
- Cannabidiol Adjunctive Therapy for Acute Bipolar Depression: A Randomized Double-Blind Placebo Controlled Trial
Principal Investigator: Yatham, Lakshmi N (Psychiatry)
Research Institute: University of British Columbia
$2,340,900 (5 years)
- Autofluorescence Imaging Guided Laser Raman Spectroscopy for Non-invasive Oral Cancer Detection
Principal Investigator: Zeng, Haishan (Dermatology and Skin Science)
Research Institute: BC Cancer
Other PI(s): Poh, Catherine
$742,051 (4 years)
UBC-led Projects awarded Priority Announcement Funding
Host Directed Therapies in Tuberculosis
Principal Investigator: Av-Gay, Yossef (Medicine)
Project Grant - PA: Pandemic and Health Emergencies Research
$750,000 (5 years)Placental sex as a biological determinant in trophoblast function and trophoblast-diected immune activity
Principal Investigator: Beristain, Alexander G (Obstetrics & Gynaecology), Robinson, Wendy P (Medical Genetics)
Project Grant - PA: Human Development, Child and Youth Health
$100,000 (1 year)Targeting the VPS13 family of lipid transport proteins to membrane contact sites
Principal Investigator: Conibear, Elizabeth (Medical Genetics)
Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)
$100,000 (1 year)Cutaneous adjuvant conditioning to enhance vaccine responses
Principal Investigator: Dutz, Jan P(Dermatology & Skin Science)
Project Grant - PA: Pandemic and Health Emergencies Research
$450,000 (3 years)Reducing health disparities among women experiencing imprisonment: an evaluation of the impact of transferring responsibility for prison healthcare to the Ministry of Health
Principal Investigator: Liauw, Jessica (Obstetrics & Gynaecology), Hutcheon, Jennifer A (Obstetrics & Gynaecology), Kouyoumdjian, Fiona G (McMaster), Slaunwhite, Amanda K (School of Population and Public Health)
Project Grant - PA: Equity in Cancer Prevention and Control
$100,000 (1 year)A Study of Reduced Dosing of the Nonavalent HPV Vaccine in Women Living with HIV
Principal Investigator: Money, Deborah M (Obstetrics & Gynaecology)
Project Grant - Priority Announcement: HIV/AIDS and STBBI
$100,000 (1 year)Advancing virtual care in stroke rehabilitation: A randomized controlled trial investigating the TeleRehabilitation with Aims to Improve Lower Extremity Recovery Post-Stroke (TRAIL) program
Principal Investigator: Sakakibara, Brodie M (Occupational Science & Occupational Therapy / Institute for Healthy Living and Chronic Disease Prevention), Tang, Ada (McMaster)
Project Grant - PA: CMA Foundation - Virtual Care
$75,000 from CMA Foundation (Ottawa, Ontario)
UBC-led Projects awarded Bridge Funding
- A.R.T. & Justice: An Arts-Based and Indigenous-Led Intervention for Strengthening Mental Health & Wellbeing for People Affected by the Canadian Carceral System
Principal Investigator: Brown, Helen J (Nursing)
$100,000
- A pragmatic randomized controlled trial evaluating the impact of a tele-asthma self-management intervention (Canadian Asthma Text Messaging Study - CANATEXTS) on reducing asthma exacerbations
Prinicipal Investigator: Fitzgerald, J M (Medicine)
$100,000